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NSI-189 Phosphate – Powder, 1 gram
NSI-189 phosphate is a synthetic benzylpiperazine-aminopyridine derivative investigated for its effects on neural progenitor cell proliferation and differentiation pathways.
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NSI-189 phosphate is a synthetic benzylpiperazine-aminopyridine derivative investigated for its effects on neural progenitor cell proliferation and differentiation pathways. Research interest centers on its reported ability to promote progenitor cell expansion and modulate neurogenesis-associated biomarkers in cell-culture and rodent models.
Unlike compounds that primarily act through monoamine transporters or neurotransmitter receptor systems, NSI-189 is studied for its influence on intracellular signalling pathways associated with progenitor cell growth, survival, and maturation.
Experimental applications include neural progenitor proliferation assays, neurogenesis biomarker analysis (including Ki-67 and doublecortin), neuronal differentiation studies, and structure-activity relationship (SAR) investigations within the benzylpiperazine-aminopyridine compound class.
The powder format supports flexible solution preparation for in vitro concentration-response studies and preclinical research protocols.
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3D Molecular Structure
Drag to rotate · scroll to zoom| Chemical Formula | C22H33N4O5P |
|---|---|
| Synonyms | NSI-189 phosphate UNII-HX0VO60T62 HX0VO60T62 NSI189 Phosphate |
| Molar Mass | 464.5 g/mol |
| CAS Number | 1270138-41-4 |
| PubChem CID | 50922680 |
| Total Compound Content | 1 gram |
| Shelf Life | 36 months |
NSI-189 phosphate is a synthetic benzylpiperazine-aminopyridine derivative investigated for its effects on neural progenitor cell biology and neurogenesis-associated pathways. In vitro proliferation assays have reported increases in progenitor cell number and modulation of neuronal differentiation markers following compound exposure. Experimental studies commonly utilize biomarkers such as doublecortin (DCX) and Ki-67 to evaluate progenitor cell proliferation, maturation, and cellular turnover. Research has also examined structural and biomarker-based endpoints in rodent neurogenesis models to characterize changes associated with prolonged exposure. Unlike classical monoaminergic pathway modulators, NSI-189 is investigated for its influence on intracellular signalling pathways associated with progenitor cell growth, differentiation, and survival. Research applications include neural progenitor proliferation assays, neurogenesis biomarker analysis, neuronal differentiation studies, intracellular signalling pathway investigation, and structure-activity relationship (SAR) research within the benzylpiperazine-aminopyridine compound class. The powder format allows preparation of stock solutions at precise molar concentrations for in vitro and preclinical research protocols. Independently third-party HPLC-tested; COA available per batch.
Every batch is independently lab tested for identity, purity and potency. View our lab testing program →
What solvent systems are typically used to prepare NSI-189 phosphate stock solutions for in vitro research?
NSI-189 phosphate is commonly prepared as a concentrated stock solution in DMSO or compatible aqueous buffers, depending on the requirements of the experimental system and target working concentration.
Solubility should be verified under specific assay conditions, and carrier concentrations should be controlled to ensure that solvent effects do not influence proliferation, differentiation, or viability endpoints. Serial dilution from a concentrated stock is typically used to achieve precise working concentrations across experimental groups.
How does the powder format support dose-titration studies?
The powder format allows preparation of custom stock solutions and precise serial dilutions across a broad concentration range. This flexibility is particularly useful for concentration-response experiments, potency determination, EC50 characterization, pathway-activation studies, and comparative evaluation of structurally related compounds.
Researchers can tailor solution concentrations to the requirements of individual assay systems without being constrained by fixed-dose formulations.
What stability considerations apply to NSI-189 phosphate during storage and solution preparation?
NSI-189 phosphate powder should be stored according to recommended storage conditions to maintain chemical integrity and experimental consistency. Prepared solutions should be evaluated for stability within the selected solvent system and used within validated storage periods.
For extended in vitro experiments, researchers commonly assess compound stability under assay conditions to ensure that observed effects reflect active compound exposure rather than degradation-related changes in concentration or activity.
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Very happy with the support team and quality was great and dispatch was incredibly fast. My laboratory research results exceeded expectations. Will purchase again soon.
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Great experience with the customer service and happy with the quality of this compound. Reordering next week. My test results are great.
